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How to administer your weight loss injection

Get confident with administering your weekly weight loss injection.

Updated over a week ago

Clinically reviewed: Wed 31 July

Most users say they can barely feel the needle when they inject! The key to this (and a seamless injection experience) is to follow the detailed step-by-step instructions that will come with your selected weight loss pen.

Make sure you read our What to do before you inject article before you get started. It’s then important to thoroughly read the injection instructions and follow all the key steps; right from preparation, to injecting, and finally to post-injection.

How do I administer Mounjaro?

Step 1 - Prepare the Pen

  • Pull the pen cap off and wipe the red inner seal with a swab.

Step 2 - Attach the Needle

  • Select a new pen needle and pull off the paper tab from the outer needle shield.

  • Push the pen needle straight onto the pen and twist the pen needle on until it is tight.

  • Pull off the outer needle shield and keep it (it will be reused).

  • Pull off the inner needle shield and put it in your household bin.

Step 3 - Prime the Pen

  • Slowly turn the dose knob until you hear 2 clicks and the extended line is shown in the dose window

  • Hold your pen with the needle pointing up and gently tap the cartridge holder to collect air bubbles at the top

  • Release some medicine into the air by pushing the dose knob until it stops, then slowly count to 5 while holding the dose knob (the 0 icon must be shown in the dose window)

  • If you do not see any medicine released while priming the pen, try again but do not repeat more than 2 additional times

  • Do not inject the needle into your body at this point.

Step 4 - Injecting the Pen

  • Turn the dose knob until it stops and the 1 icon is shown in the dose window

  • Insert the needle into your skin (into your pre-chosen injection site)

  • Inject the medicine by pushing the dose knob in until it stops then slowly count to 5 while continuing to hold the dose knob

  • Check the 0 icon is now showing in the dose window and pull the needle out of your skin

Step 4 - After injecting

  • If you see a pinprick of blood after removing the needle (this is normal) lightly press the injection site with a cotton ball (do not rub)

  • Carefully replace the outer needle shield that you set aside earlier

  • Unscrew the capped needle and place into your supplied sharps container

  • Replace the pen cap (never store the pen with a needle attached and always store with the pen cap securely on)

  • Now your pen has been used it can be stored at room temperature up to 30°C for no more than 30 days (out of direct sunlight, heat and from the sight & reach of children)

  • If you’ve injected your 4th dose from the pen, the pen (not the needle) can be disposed of in your regular household bin, or taken to a local pharmacy for disposal


For further details, read the Mounjaro injection user guide and follow the steps – read here.

Watch our handy Mounjaro injection video - watch here.

How do I administer Wegovy?

Read the Wegovy injection user guide and follow all the steps – read here.

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